Overview of research area

Elucidation of the principles for ultra high-speed measurement and manipulation techniques and tissue function expression for BioAssembler, which will construct 3D cellular systems that function in in vitro environments based on micro-nano robotics.

There is organic linkage between our three research topics: “Measurement and control of cell characteristics,” in which physical properties of cells taken from living organisms are measured at ultra high speed and active cells that are useful in building cell systems are separated; “Construction of three-dimensional cellular systems,” in which 3D cellular systems with complex morphologies are shaped and assembled; and “Analysis and evaluation of three-dimensional cellular systems,” in which growth, differentiation-inducing, and morphogenesis controls and transplantation responses of the 3D cellular systems that were made are analyzed and evaluated, functional elucidation as well as comparison and verification are done in vitro, and attempts are made to apply to regenerative medicine. Artificial 3D cellular systems will be created that have morphologies and actions that are useful in medical engineering.

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Research content

Our aim is to greatly raise the level of basic technology for regenerative medicine by constructing 3D cellular systems in in vitro environments, creating 3D tissues suitable for medical applications, and elucidating the functions that make these cell systems act as tissues. For this purpose, we shall develop and illustrate the following.

  • Establish techniques to grow cells extracted from living organisms, and perform ultra high-speed separation of active cells that are useful in tissue formation. We aim to understand the multifaceted properties of cells and, focusing on these properties, to propose the world’s fastest measurement and separation techniques with the application of micro-nano robotics.
  • Demonstrate the construction of 3D cellular systems that function as tissue, and propose breakthrough construction technologies for 3D cellular systems with the application of micro-nano robotics, starting from construction of complex tissue systems and ultimately looking at formation of tissue with a high oxygen requirement.
  • In the process of building 3D cellular systems in an in vitro environment, we intend to clarify the characteristics of the dynamic environments that multicellular systems need for initiation of growth, differentiation, and morphogenesis, and illuminate the mechanisms through which 3D cellular systems function as tissue. Going through the three cycles above, we will create an artificial 3D cellular system that is useful in regenerative medicine, and establish breakthrough measurement-control technology with the application of micro-nano robotics.